Title:
新規分子機能の進化
Document Type and Number:
Japanese Patent JP2004536162
Kind Code:
A
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogues to the amplification of natural biopolymer such as polynucleotides and protein.
Inventors:
Riu, David Earl.
Gartner, Zev Jay.
Canaan, Matthew W.
Gartner, Zev Jay.
Canaan, Matthew W.
Application Number:
JP2002574322A
Publication Date:
December 02, 2004
Filing Date:
March 19, 2002
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C12N15/09; C07B61/00; C08G85/00; C12N15/10; C12P1/00; C12P19/34; C12P21/00; (IPC1-7): C08G85/00; C07B61/00; C12N15/09
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita