Title:
GM1ガングリオシドを阻害することによる、鎮痛効力を増大し、そして、ニ峰作用性オピオイドアゴニストの有害な興奮性効果を減弱する方法。
Document Type and Number:
Japanese Patent JP2005500258
Kind Code:
A
Abstract:
The present invention provides a method for increasing analgesic potency of a bimodally-acting opioid agonist in a subject, by inhibiting GM1-ganglioside in nociceptive neurons. The present invention further provides a method for treating pain in a subject in need of treatment thereof. Also provided in the present invention is a method for treating chronic pain in a subject in need of treatment thereof. Additionally, the present invention provides a method for treating tolerance to or an addiction to a bimodally-acting opioid agonist in a subject in need of treatment thereof. Finally, the present invention provides a pharmaceutical composition of analgesic agents and a pharmaceutically-acceptable carrier.
Inventors:
Klein, Stanley M.
Shen, Kafei
Shen, Kafei
Application Number:
JP2002574904A
Publication Date:
January 06, 2005
Filing Date:
March 19, 2002
Export Citation:
Assignee:
Albert Einstein College of Medicine of Yeshiva University
International Classes:
A61K45/06; A61K31/00; A61K31/135; A61K31/137; A61K31/215; A61K31/4465; A61K31/451; A61K31/4748; A61K31/485; A61K33/00; A61K33/04; A61K38/00; A61K38/22; A61K38/33; A61K39/395; A61P25/04; A61P25/20; A61P43/00; (IPC1-7): A61K45/06; A61K31/135; A61K31/137; A61K31/4465; A61K31/451; A61K31/4748; A61K31/485; A61K33/04; A61K38/00; A61K38/22; A61K39/395; A61P25/04; A61P25/20; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita