Title:
神経因性鎮痛薬としてのプレグナン-ジオンまたはジオールの使用
Document Type and Number:
Japanese Patent JP2005504776
Kind Code:
A
Abstract:
The present invention relates to the use of pregnanes in inducing analgesia, preferably without overt sedation, in a mammal in response to neuropathic pain, and compositions and kits therefore.
Inventors:
GOODCHILD,Colin,Stanley
NADESON,Raymond
NADESON,Raymond
Application Number:
JP2003522545A
Publication Date:
February 17, 2005
Filing Date:
August 28, 2002
Export Citation:
Assignee:
Monash University
International Classes:
A61K31/4468; A61K31/485; A61K31/57; A61K31/573; A61P25/04; C07J5/00; A61K45/00; (IPC1-7): A61K31/573; A61K31/4468; A61K31/485; A61K45/00; A61P25/04; C07J5/00
Domestic Patent References:
| JPH11509844A | 1999-08-31 |
Foreign References:
| WO2001016601A1 | 2001-03-08 | |||
| US6048848A | 2000-04-11 | |||
| WO1997007807A1 | 1997-03-06 |
Other References:
JPN6009025168, 山本達郎, "ＮＭＤＡレセプタと疼痛", 麻酔, 1996, ４５（１１）, ｐ． １３１２−１３１８
JPN6009025165, ＷＩＮＦＲＥＥ， Ｃ． Ｊ．, "Ａｎａｌｇｅｓｉｃ ｅｆｆｅｃｔｓ ｏｆ ｉｎｔｒａｔｈｅｃａｌｌｙ−ａｄｍｉｎｉｓｔｅｒｅｄ ３α−ｈｙｄｒｏｘｙ−５α−ｐｒｅｇｎａｎ−２０−ｏｎｅ ｉｎ ａ ｒａｔ ｍｅｃｈａｎｉｃａｌ ｖ", Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ, 1992, ５０（１４）, ｐ． １００７−１０１２
JPN6009025166, ＮＡＤＥＳＯＮ， Ｒ．, "Ａｎｔｉｎｏｃｉｃｅｐｔｉｖｅ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｎｅｕｒｏｓｔｅｒｏｉｄｓ ＩＩ． Ｅｘｐｅｒｉｍｅｎｔｓ ｗｉｔｈ Ｓａｆｆａｎ ａｎｄ ｉｔｓ ｃｏｍｐｏｎｅｎｔｓ ａｌｐｈａｘａｌｏ", Ｐａｉｎ, 2000, ８８（１）, ｐ． ３１−３９
JPN6009025165, ＷＩＮＦＲＥＥ， Ｃ． Ｊ．, "Ａｎａｌｇｅｓｉｃ ｅｆｆｅｃｔｓ ｏｆ ｉｎｔｒａｔｈｅｃａｌｌｙ−ａｄｍｉｎｉｓｔｅｒｅｄ ３α−ｈｙｄｒｏｘｙ−５α−ｐｒｅｇｎａｎ−２０−ｏｎｅ ｉｎ ａ ｒａｔ ｍｅｃｈａｎｉｃａｌ ｖ", Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ, 1992, ５０（１４）, ｐ． １００７−１０１２
JPN6009025166, ＮＡＤＥＳＯＮ， Ｒ．, "Ａｎｔｉｎｏｃｉｃｅｐｔｉｖｅ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｎｅｕｒｏｓｔｅｒｏｉｄｓ ＩＩ． Ｅｘｐｅｒｉｍｅｎｔｓ ｗｉｔｈ Ｓａｆｆａｎ ａｎｄ ｉｔｓ ｃｏｍｐｏｎｅｎｔｓ ａｌｐｈａｘａｌｏ", Ｐａｉｎ, 2000, ８８（１）, ｐ． ３１−３９
Attorney, Agent or Firm:
Shintaro Nogawa