Title:
鏡像異性的に純粋なアミノ置換縮合二環式環の合成
Document Type and Number:
Japanese Patent JP2005508316
Kind Code:
A
Abstract:
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
Inventors:
McIkhan, Ernest Jay.
Bridger, Gary Jay.
Skpinska, Christina A.
Skull Jay, Renato Tea.
Bridger, Gary Jay.
Skpinska, Christina A.
Skull Jay, Renato Tea.
Application Number:
JP2003526864A
Publication Date:
March 31, 2005
Filing Date:
September 12, 2002
Export Citation:
Assignee:
Anomed Incorporated
International Classes:
C07D215/06; C07D215/20; C07D215/38; C07D215/40; C07D215/42; C07D215/44; C07D215/48; C07D217/02; C07D221/04; C07D241/40; C07D241/42; C12P17/12; C07D307/79; C07D491/04; C07D491/052; (IPC1-7): C07D215/38; C07D215/40; C07D215/44; C07D215/48; C07D217/02; C07D221/04; C07D241/40; C07D307/79; C07D491/052; C12P17/12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita