Title:
スルホンアミドプロドラックの経口剤形
Document Type and Number:
Japanese Patent JP2005509002
Kind Code:
A
Abstract:
A pharmaceutical composition that is substantially free of water comprises at least one orally deliverable dosage unit comprising a therapeutically effective amount of a sulfonamide prodrug and, where the prodrug is readily degradable ex vivo, has means to inhibit such degradation prior to oral administration. Illustratively the prodrug is parecoxib or a water-soluble salt thereof, and the composition has means to inhibit conversion of the parecoxib to valdecoxib. A method of treating or preventing a COX-2 mediated disorder in a subject comprises (a) dissolving at least one dosage unit of such a composition in a pharmaceutically acceptable aqueous vehicle to form a solution, and (b) orally administering the solution to the subject before substantial precipitation of insoluble matter occurs in the solution.
Inventors:
Karim, Aziz
Nema, Sandeep
Ewing, Gary, Dee.
Nema, Sandeep
Ewing, Gary, Dee.
Application Number:
JP2003543592A
Publication Date:
April 07, 2005
Filing Date:
November 12, 2002
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K47/48; A61K9/08; A61K9/14; A61K9/19; A61K9/20; A61K31/365; A61K31/415; A61K31/42; A61K47/10; A61K47/20; A61K47/22; A61K47/26; A61K47/46; A61P29/00; A61P43/00; (IPC1-7): A61K47/48; A61K9/08; A61K9/14; A61K9/19; A61K9/20; A61K31/415; A61K31/42; A61K47/10; A61K47/20; A61K47/22; A61K47/26; A61K47/46; A61P43/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama