Title:
シンバスタチンの製造方法
Document Type and Number:
Japanese Patent JP2005514419
Kind Code:
A
Abstract:
Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin.
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Inventors:
Li, Jehon
Ha, tehi
Park, Churhun
Li, hechul
Li, Gwangsun
Chan, Yunkill
Ha, tehi
Park, Churhun
Li, hechul
Li, Gwangsun
Chan, Yunkill
Application Number:
JP2003557999A
Publication Date:
May 19, 2005
Filing Date:
December 26, 2002
Export Citation:
Assignee:
Hammi Farm. Seeo., LDT.
International Classes:
C07D309/06; A61K31/366; A61P3/06; A61P25/28; C07D309/30; C07F7/18; (IPC1-7): C07D309/30; A61K31/366; A61P3/06; A61P25/28
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto