Title:
免疫学的欠損を有する患者において免疫応答性を回復するための、組成物および方法
Document Type and Number:
Japanese Patent JP2005517025
Kind Code:
A
Abstract:
The present invention relates generally to methods for stimulating, activating and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signalling enhancement. Also provided are methods for producing T-cells for the use in diagnostics and the treatment of a variety of indications, including cancer, viral infection and immune related disorders. Compositions of cells having increased polyclonality produced by these processes are further provided.
Inventors:
Bonnie hady, mark
Berenson, Ronald Jay.
Berenson, Ronald Jay.
Application Number:
JP2003566523A
Publication Date:
June 09, 2005
Filing Date:
February 07, 2003
Export Citation:
Assignee:
Excite Therapy, Inc.
International Classes:
C12N5/10; A61K35/14; A61K35/26; A61L27/38; A61P1/04; A61P3/10; A61P5/14; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; C07K16/28; C12N5/02; C12N5/0783; A61K35/12; A61K39/00; (IPC1-7): A61K35/14; A61K35/26; A61P1/04; A61P3/10; A61P5/14; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; C12N5/10
Foreign References:
| WO2001062895A2 | 2001-08-30 | |||
| WO2001089539A2 | 2001-11-29 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita