Title:
Gタンパク質結合受容体(GPCR)のためのリガンドとしてのテトラヒドロカルバゾール誘導体
Document Type and Number:
Japanese Patent JP2005518375
Kind Code:
A
Abstract:
The invention relates to novel tetrahydrocarbozole derivatives acting as ligands for G-protein coupled receptors (GPCR), especially as antagonists of gonadotropin-releasing hormone (GnRH). The invention also relates to a pharmaceutical composition containing said novel tetrahydrocarbozole derivatives, and to a method for producing the same. Furthermore, the invention relates to the administration of tetrahydrocarbozole derivatives for the treatment of pathological conditions mediated by GPCR, especially for the inhibition of GnRH, to mammals, especially humans, requiring such treatment, and to the use of tetrahydrocarbozole derivatives for producing a pharmaceutical agent for treating pathological conditions mediated by GPCR, especially for the inhibition of GnRH.
Inventors:
Marx Copitz
Hans Peter Moon
Ken Show
Holger Hess-Stump
Claus Pauli
Hans Peter Moon
Ken Show
Holger Hess-Stump
Claus Pauli
Application Number:
JP2003552724A
Publication Date:
June 23, 2005
Filing Date:
December 16, 2002
Export Citation:
Assignee:
Zentaris GmbH
International Classes:
A61K31/403; A61K31/4439; A61K38/00; A61P15/00; A61P15/08; A61P35/00; A61P43/00; C07D209/00; C07D209/86; C07D209/88; C07D401/06; C07D401/12; C07K5/02; (IPC1-7): C07D209/88; A61K31/403; A61K31/4439; A61K38/00; A61P15/00; A61P15/08; A61P35/00; A61P43/00; C07D401/06
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard