Title:
エポチロン誘導体およびアルキル化剤を含む組合せ剤
Document Type and Number:
Japanese Patent JP2005522461
Kind Code:
A
Abstract:
The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.
Inventors:
Judith Rose Anderson
John David Rossermel
Paul M Jay Maxiehe
Alan body
John David Rossermel
Paul M Jay Maxiehe
Alan body
Application Number:
JP2003574174A
Publication Date:
July 28, 2005
Filing Date:
March 07, 2003
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/425; A61K31/427; A61K31/565; A61K45/06; A61P35/00; A61P35/02; A61P35/04; A61P43/00; A61K45/00; (IPC1-7): A61K31/427; A61K31/565; A61K45/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00
Domestic Patent References:
| JP2002537395A | 2002-11-05 | |||
| JP2003500394A | 2003-01-07 | |||
| JP2004506638A | 2004-03-04 | |||
| JP2003518359A | 2003-06-10 |
Foreign References:
| WO2000050423A1 | 2000-08-31 | |||
| WO2000071521A1 | 2000-11-30 | |||
| WO2002014323A2 | 2002-02-21 | |||
| WO1999042578A2 | 1999-08-26 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima