プロテインキナーゼ阻害剤として有用なインダゾール化合物

Japanese Patent JP2005524631

A

The present invention provides compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2 and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

Vinci, Hayley
Brencherry, Guy
Gorek, Julian M. C.
Ronald Negtel
Mortymore, Michael
Patel, Sanjay
Rutherford, Alstyer

JP2003564020A

August 18, 2005

January 23, 2003

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VERTEX PHARMACEUTICALS INCORPORATED

A61K31/41; A61K31/416; A61K31/4178; A61K31/42; A61K31/422; A61K31/427; A61K31/4439; A61K31/496; A61K31/5377; A61K45/00; A61P1/16; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P19/00; A61P19/10; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07D231/56; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/10; C07D413/12; C07D417/10; C07D417/12; (IPC1-7): C07D231/56; A61K31/41; A61K31/416; A61K31/4178; A61K31/42; A61K31/422; A61K31/427; A61K31/4439; A61K31/496; A61K31/5377; A61K45/00; A61P1/16; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P19/00; A61P19/10; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/10; C07D413/12; C07D417/10; C07D417/12

WO2001056988A1	2001-08-09
WO2002100833A1	2002-12-19
US20020103229A1	2002-08-01

J.MED.CHEM., vol. 11(1), JPN6009032630, 1968, pages 74 - 79, ISSN: 0001359136

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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