Title:
幹細胞および癌幹細胞を同定および単離する方法
Document Type and Number:
Japanese Patent JP2005528115
Kind Code:
A
Abstract:
Methods and compositions are provided for the identification of stem cells and cancer stem cells. beta-catenin is also identified as a target for the development of therapeutic moieties against hematopoietic tumors, i.e. leukemia and lymphoma cells, which may include screening assays directed at beta-catenin, or members of the beta-catenin signaling pathway. Cellular proliferation in hematopoietic cells can be altered by introducing stabilized beta-catenin into a hematopoietic cell that is altered in its ability to undergo apoptosis but which is not fully transformed. The immortalized cells are useful in screening assays, and in the analysis of pathways by which hematopoietic cells undergo transformation.
Inventors:
Jamison Catriona Helen Em.
Elles Laurier Elizabeth
Leya Tanishta
Weissman Irving El.
Elles Laurier Elizabeth
Leya Tanishta
Weissman Irving El.
Application Number:
JP2004510451A
Publication Date:
September 22, 2005
Filing Date:
May 30, 2003
Export Citation:
Assignee:
The Board of Trustees of the Leland Stanford Junior University
International Classes:
G01N33/50; C12N5/06; C12N5/08; C12N5/10; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/567; (IPC1-7): C12Q1/68; C12N5/10; C12N15/09; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
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