Title:
抗原提示細胞の生成方法
Document Type and Number:
Japanese Patent JP2005528899
Kind Code:
A
Abstract:
Described is a method for the generation of antigen-presenting cells (APC), preferably bone marrow-derived dendritic cells (BMDC) or peripheral blood-derived dendritic cells, as antigen carrier having immunostimulatory properties for anti-infective treatment comprising the steps of (a) pulsing the APC with antigen and (b) treating the APC with a CpG oligonucleotide. Said APC are useful as an immune prophylactic or immune therapeutic agent against diseases like AIDS, tuberculosis, malaria or leishmaniasis.
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Inventors:
Ramirec-Pineda, Robinson
Mole, Hydran
Mole, Hydran
Application Number:
JP2004508281A
Publication Date:
September 29, 2005
Filing Date:
May 27, 2003
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C12N15/09; A61K35/14; A61K35/28; A61K38/00; A61K39/00; A61K39/008; A61P31/04; A61P35/00; C12N5/0784; C12N5/10; (IPC1-7): C12N5/10; A61K35/14; A61K35/28; A61K38/00; A61K39/00; A61P31/04; A61P35/00
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata