Title:
7-置換-3-キノリンおよび3-キノール-4-オンカルボニトリル類の調製法
Document Type and Number:
Japanese Patent JP2005529907
Kind Code:
A
Abstract:
There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer.
Inventors:
Anna Carolina Barrios Sosa
Janon Daniel One
Stephen Lawrence Johnson
Dan Marten Burger
Janon Daniel One
Stephen Lawrence Johnson
Dan Marten Burger
Application Number:
JP2004501380A
Publication Date:
October 06, 2005
Filing Date:
April 29, 2003
Export Citation:
Assignee:
Wyeth Holdings Corporation
International Classes:
A61K31/4704; A61K31/4709; A61K31/554; A61P35/00; A61P43/00; C07D215/22; C07D215/54; C07D215/56; C07D401/12; C07D401/14; C07D405/12; C07D409/12; C07D417/12; (IPC1-7): C07D215/54; A61K31/4704; A61K31/4709; A61K31/554; A61P35/00; A61P43/00; C07D401/12; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita