Title:
骨喪失を治療するためのカテプシンK阻害剤としての1-(オキソアミノアセチル)ペンチルカルバマート誘導体
Document Type and Number:
Japanese Patent JP2005532290
Kind Code:
A
Abstract:
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim 1, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
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Inventors:
Barrett, David, Jean
Catalano, John, Gee.
Deaton, David, Norman
Miller, Aaron, Vine
Ray, John, A
Samano, vicente
Catalano, John, Gee.
Deaton, David, Norman
Miller, Aaron, Vine
Ray, John, A
Samano, vicente
Application Number:
JP2003583404A
Publication Date:
October 27, 2005
Filing Date:
April 01, 2003
Export Citation:
Assignee:
SmithKline Beechham Corporation
International Classes:
A61K31/341; A61K31/365; A61K31/40; A61K31/4015; A61K31/4025; A61K31/404; A61K31/4155; A61K31/416; A61K31/4192; A61K31/42; A61K31/422; A61K31/4245; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/4709; A61K31/497; A61K31/5377; A61P19/00; A61P19/10; A61P43/00; C07D207/12; C07D207/263; C07D207/27; C07D207/273; C07D207/48; C07D307/20; C07D307/33; C07D401/06; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D409/06; C07D409/12; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/06; C07D417/12; C07D417/14; C07D207/26; (IPC1-7): C07D207/12; A61K31/341; A61K31/365; A61K31/40; A61K31/4015; A61K31/4025; A61K31/404; A61K31/4155; A61K31/416; A61K31/4192; A61K31/42; A61K31/422; A61K31/4245; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/4709; A61K31/497; A61K31/5377; A61P19/00; A61P19/10; A61P43/00; C07D207/263; C07D207/273; C07D307/20; C07D307/33; C07D401/06; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D409/06; C07D409/12; C07D413/06; C07D413/14; C07D417/04; C07D417/06; C07D417/12; C07D417/14
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita