Title:
HPV-16ウィルスの突然変異したE7蛋白から成る非免疫抑制性の免疫原またはワクチン
Document Type and Number:
Japanese Patent JP2005532298
Kind Code:
A
Abstract:
The invention relates to an immunogenic or vaccine composition inducing an immune response towards the HPV-16 Papillomavirus native E7 protein, without simultaneously inducing an immunosuppression, said composition comprising, as the active ingredient, a non immunosuppressive mutated E7 protein, comprising the amino acid sequence consisting, from the N-terminal end to the C-terminal end, in: i. the 1-19 amino acid sequence of sequence SEQ ID No. 3; ii. an amino acid sequence possessing (a) the substitution of at least one amino acid, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3 or (b) the deletion of at least four consecutive amino acids, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3; and iii. the 30-98 amino acid sequence of sequence SEQ ID No 3.
Inventors:
Zaguri, Daniel
Le Buennec, Helene
Bizini, Bernard
Cohen paul
Le Buennec, Helene
Bizini, Bernard
Cohen paul
Application Number:
JP2003587306A
Publication Date:
October 27, 2005
Filing Date:
April 04, 2003
Export Citation:
Assignee:
Neovac
International Classes:
A61K39/00; A61K39/39; A61K39/395; A61P31/12; A61P35/00; A61P37/04; C07K14/01; C07K14/025; C07K14/16; C07K16/08; C12N15/37; (IPC1-7): A61K39/00; A61K39/39; A61K39/395; A61P31/12; A61P35/00; C07K16/08
Attorney, Agent or Firm:
Takashi Koshiba