Title:
エボラウイルスヌクレオキャプシドの構築に関するアッセイ
Document Type and Number:
Japanese Patent JP2005533111
Kind Code:
A
Abstract:
The present invention relates to assays for the identification of compounds that inhibit assembly of NP, VP35, and VP24, or inhibit the glycosylation of NP, required for nucleocapsid formation, for use as anti-viral agents. The invention also relates to assays for the identification of compounds that block glycosylation of proteins having a glycosylation domain that is substantially homologous to a glycosylation domain of NP required for polymerization. The invention further relates to pseudoparticles for presentation of antigens or antigenic epitopes for immunogenic or vaccination purposes.
Inventors:
Nebel, Gully
Fan, Yue
Fan, Yue
Application Number:
JP2004521699A
Publication Date:
November 04, 2005
Filing Date:
July 11, 2003
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
G01N33/50; A61K39/00; A61K39/12; A61K39/17; A61K45/00; A61P31/12; C07K14/08; C12Q1/02; C12Q1/18; C12Q1/34; C12Q1/70; G01N33/15; G01N33/569; (IPC1-7): C07K14/08; A61K39/00; A61K45/00; A61P31/12; C12Q1/02; C12Q1/34; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama