Title:
結節性硬化症の診断法および治療法
Document Type and Number:
Japanese Patent JP2005535332
Kind Code:
A
Abstract:
The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
Inventors:
Guan Khun-Rian
Application Number:
JP2004528088A
Publication Date:
November 24, 2005
Filing Date:
August 12, 2003
Export Citation:
Assignee:
The Regents of the University of Michigan
International Classes:
G01N33/50; A61K31/277; A61K31/353; A61K31/436; A61K31/4745; A61K31/7004; A61K31/7056; A61K45/00; A61P9/00; A61P35/00; C07D498/18; C12Q1/02; C12Q1/42; C12Q1/48; G01N33/15; G01N33/53; G01N33/537; G01N33/543; A61B; (IPC1-7): C12Q1/48; A61K31/277; A61K31/353; A61K31/436; A61K31/7004; A61K31/7056; A61K45/00; A61P9/00; A61P35/00; C12Q1/02; G01N33/15; G01N33/50
Other References:
JPN6009039597, Ｍｏｌｅｃｕｌａｒ Ｃｅｌｌ, 200207, Ｖｏｌ．１０, ｐ．１５１−１６２
JPN6009039598, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 20020603, Ｖｏｌ．２７７， Ｎｏ．３４, ｐ．３０９５８−３０９６７
JPN6009039599, Ｈｕｍａｎ Ｍｏｌｅｃｕｌａｒ Ｇｅｎｅｔｉｃｓ, 200203, Ｖｏｌ．１１， Ｎｏ．５, ｐ．５２５−５３４
JPN6010056773, ＳＣＩＥＮＣＥ, 2001, Ｖｏｌ．２９４, ｐ．１１０２−１１０５
JPN6010056774, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 2001, Ｖｏｌ．２７６， Ｎｏ．４１, ｐ．３７９８６−３７９９２
JPN6010056776, Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ, 2000, Ｖｏｌ．１９， Ｎｏ．１１, ｐ．２５３７−２５４８
JPN6010056779, Ｃｅｌｌ, 1999, Ｖｏｌ．９６, ｐ．５２９−５３９
JPN6009039598, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 20020603, Ｖｏｌ．２７７， Ｎｏ．３４, ｐ．３０９５８−３０９６７
JPN6009039599, Ｈｕｍａｎ Ｍｏｌｅｃｕｌａｒ Ｇｅｎｅｔｉｃｓ, 200203, Ｖｏｌ．１１， Ｎｏ．５, ｐ．５２５−５３４
JPN6010056773, ＳＣＩＥＮＣＥ, 2001, Ｖｏｌ．２９４, ｐ．１１０２−１１０５
JPN6010056774, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 2001, Ｖｏｌ．２７６， Ｎｏ．４１, ｐ．３７９８６−３７９９２
JPN6010056776, Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ, 2000, Ｖｏｌ．１９， Ｎｏ．１１, ｐ．２５３７−２５４８
JPN6010056779, Ｃｅｌｌ, 1999, Ｖｏｌ．９６, ｐ．５２９−５３９
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi