Title:
ヒドロキシアザピロンの改良合成法
Document Type and Number:
Japanese Patent JP2005535708
Kind Code:
A
Abstract:
This invention describes a process for preparing hydroxyazapirones of Formula I from azapirones of Formula II. The process comprises treating azapirones with a strong base, monitoring enolate formation of the azapirone by IR spectroscopy, and reacting the enolate with a source of molecular oxygen in the presence of a reductant. The process is suitable for large scale production of hydroxyazapirones.
Inventors:
Jeffrey DePuy
Atul es Kotonis
Raeun Simon
Eric Di Daudi
Daniel Jay Watson
Atul es Kotonis
Raeun Simon
Eric Di Daudi
Daniel Jay Watson
Application Number:
JP2004527926A
Publication Date:
November 24, 2005
Filing Date:
August 07, 2003
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/495; C07D401/12; C07D401/14; (IPC1-7): C07D401/12
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa