ペプチドアミド化方法

Title:

ペプチドアミド化方法

Document Type and Number:

Japanese Patent JP2005536470

Kind Code:

A

Abstract:

The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2-X3, wherein X2 is any amino acid, X3 is an amino acid selected from the group consisting of cysteine, histidine, or methionine, and wherein the carboxyl-terminus of the peptide is amidated upon cleavage at the X1-cysteine sequence.

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Inventors:

Seo Jin Seog
Burton Homequist
Daniel Streidam

Application Number:

JP2004508108A

Publication Date:

December 02, 2005

Filing Date:

May 23, 2003

Export Citation:

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Assignee:

RESTORAGEN, INC.

International Classes:

C12N15/09; C07K1/00; C07K1/107; C07K5/103; C07K5/107; C07K5/113; C07K7/06; C07K7/08; C07K14/575; C07K14/60; C12N1/21; C12P21/06; (IPC1-7): C07K1/107; C07K14/575; C07K14/60

Domestic Patent References:

JPH05213837A

1993-08-24

Foreign References:

US5352771A

1994-10-04

Attorney, Agent or Firm:

Kyousei Tamura
Hiromitsu Takayama
Minato Saito

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