Title:
1-メチル-2-(4-アミジノフェニルアミノメチル)-ベンズイミダゾール-5-イル-カルボン酸-(N-2-ピリジル-N-2-ヒドロキシカルボニルエチル)-アミドの新規プロドラッグ、それらの製造及び医薬組成物としてのそれらの使用
Document Type and Number:
Japanese Patent JP2005536528
Kind Code:
A
Abstract:
1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazole-5-carboxylic acid N-(2-pyridyl)-N-(2-carboxyethyl)-amide prodrugs (I) are new. 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazole-5-carboxylic acid N-(2-pyridyl)-N-(2-carboxyethyl)-amide prodrugs of formula (I) and their tautomers and salts are new. R' = H or 1-6C (preferably 1-3C) alkyl; R = COOMe or OH; and provided that either: (1) R' is H and R is COOMe; or (2) R is OH and R' is H or 1-6C alkyl. An Independent claim is included for the preparation of (I).
Inventors:
Howell norbert
Bousch Ulrich
Kolbakki Florian
Bousch Ulrich
Kolbakki Florian
Application Number:
JP2004526797A
Publication Date:
December 02, 2005
Filing Date:
July 28, 2003
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft
International Classes:
A61K31/4439; A61P7/02; A61P43/00; C07D401/12; (IPC1-7): C07D401/12; A61K31/4439; A61P7/02; A61P43/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama