Title:
CCR-3レセプターアンタゴニストIXとしての2,5-置換ピリミジン誘導体
Document Type and Number:
Japanese Patent JP2006502107
Kind Code:
A
Abstract:
Compounds of Formula (I): wherein Ar1 is aryl; Ar2 is hydrogen, cycloalkyl, aryl or heteroaryl; Z is -C(-O) or a single bond; R1, R2, R3, R4 and R5 are independently hydrogen or alkyl optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon atoms; X is -O-, -NRh (where Rh is hydrogen or alkyl), (CR6R7)m(where R6 and R7 are independently in each occurrence hydrogen or alkyl and m is an integer from 0 to 3), or -S(O)n (wherein n is an integer from 0 to 2); or prodrugs thereof, and pharmaceutically acceptable salts thereof, are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.
Inventors:
Du Voice, Daisy Joe
Mao, Ron
Rogers, Daniel Harry
William Patrick, John Patrick
Mao, Ron
Rogers, Daniel Harry
William Patrick, John Patrick
Application Number:
JP2004518572A
Publication Date:
January 19, 2006
Filing Date:
June 25, 2003
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D401/12; A61K31/506; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P31/18; A61P37/08; A61P43/00; C07D401/14; C07D405/14; C07D409/14
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda