Title:
肥満の治療のためのメラノコルチン受容体リガンドとしての2-アルキル-(2-アミノ-3-アリール-プロピオニル)-ピペラジン誘導体及び関連化合物
Document Type and Number:
Japanese Patent JP2006506384
Kind Code:
A
Abstract:
The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1-C12 linear or branched alkyl, C3-C8 cyclic alkyl, C2-C12 linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R1 is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R7a is selected from the group consisting of hydrogen, -CO2H, -CONH2, -CONHCH3, and -CON(CH3)2; R8 is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.
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Inventors:
Frank Hallock Evecino
Tian Shin Long
Weslow Adam Maser
Annie-Odyl Corson
Tian Shin Long
Weslow Adam Maser
Annie-Odyl Corson
Application Number:
JP2004546990A
Publication Date:
February 23, 2006
Filing Date:
October 22, 2003
Export Citation:
Assignee:
THE PROCTER & GAMBLE COMPANY
International Classes:
C07D241/08; A61K31/4725; A61K31/495; A61K31/496; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P5/24; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P15/00; A61P15/06; A61P15/08; A61P15/10; A61P19/02; A61P19/06; A61P21/00; A61P25/00; A61P25/14; A61P25/28; A61P29/00; A61P31/04; A61P35/00; C07D241/04; C07D401/12; C07D403/12; C07K14/72
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe