Title:
眼内損傷を治療および予防するためのROM生成および放出阻害剤の使用
Document Type and Number:
Japanese Patent JP2006512279
Kind Code:
A
Abstract:
A method of treating or preventing intraocular damage caused by reactive oxygen metabolites is provided. The method includes identifying a subject presenting the symptoms of proliferative diabetic retinopathy; and administering to at least one eye of the subject a pharmaceutically acceptable solution containing an effective concentration of a compound effective to reduce the amount of ROM in an individual. The compounds effective to reduce the amount of ROM in an individual include histamine and histamine related compounds. The specific disease states characterized by intraocular damage caused by reactive oxygen metabolites include proliferative diabetic retinopathy, preproliferative diabetic retinopathy, proliferative retinopathy, age-related macular degeneration, retinitis pigmentosa, and macular holes. A pharmaceutical composition including a pharmaceutically acceptable ophthalmic solution containing an effective concentration of a compound effective to reduce the amount of ROM in an individual is likewise provided.
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Inventors:
Gaelsen, Kurt Earl.
Application Number:
JP2003579630A
Publication Date:
April 13, 2006
Filing Date:
March 28, 2003
Export Citation:
Assignee:
MAXIM PHARMACEUTICALS, INC.
International Classes:
A61K45/00; A61K31/07; A61K31/203; A61K31/355; A61K31/375; A61K31/4045; A61K31/417; A61K31/4172; A61K31/675; A61K38/00; A61K38/06; A61K38/16; A61K38/20; A61K38/43; A61K38/44; A61K39/00; A61P27/00; A61P27/02; A61B
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama
Hidemi Matsukura
Yutaka Nagata
Tsutomu Toyama