Title:
乾癬及び他の皮膚疾患治療におけるシクロパミンの使用
Document Type and Number:
Japanese Patent JP2006512281
Kind Code:
A
Abstract:
This invention concerns the use of cyclopamine, a naturally occurring steroidal alkaloid known for over thirty years, for the treatment of psoriasis and achievement of rapid clearance of the psoriatic skin lesions together with the reversion of the histopathological signs of disease to normalcy with no detectable side effects. The cyclopamine-induced clearance of psoriatic lesions from the skin of patients is associated with the causation of cellular differentiation in lesional epidermis and with the rapid disappearance of CD4(+) lymphocytes and other inflammatory cells from lesional skin. Therapeutic compositions comprising of cyclopamine and a corticosteroid and/or the pre-treatment of lesions with a corticosteroid provide significantly further increased therapeutic effectiveness over the use of cyclopamine alone or a corticosteroid alone.
Inventors:
Tas, Sinan
Avuchi, Octi
Avuchi, Octi
Application Number:
JP2003585716A
Publication Date:
April 13, 2006
Filing Date:
March 17, 2003
Export Citation:
Assignee:
Tas, Sinan
International Classes:
A61K31/4355; A61K8/63; A61K31/57; A61K31/573; A61P17/06; A61P35/00; A61Q19/00; C07D491/048
Domestic Patent References:
| JP2002511415A | 2002-04-16 |
Foreign References:
| WO2000041545A2 | 2000-07-20 | |||
| WO2001027135A2 | 2001-04-19 | |||
| WO2000074706A1 | 2000-12-14 | |||
| EP1360958A2 | 2003-11-12 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Eiji Katayama
Junko Kobayashi
Norio Omori