Title:
成長ホルモンの結晶を製造するための方法
Document Type and Number:
Japanese Patent JP2006513986
Kind Code:
A
Abstract:
A process is provided for manufacturing crystals of growth hormone (GH), or functional derivatives thereof, comprising the following steps : (a) preparing an aqueous solution of GH, or functional derivatives thereof, comprising 2-propanol, (b) incubating the solution prepared in step (a) to crystallize said GH, or functional derivatives thereof, and (c) isolating the crystals formed in step (b). A novel use of 2-propanol as a crystallizing agent for manufacturing crystals of GH, or functional derivatives thereof is also provided. In addition, crystals obtainable by the process and pharmaceutical compositions comprising the crystals are provided. The crystals are useful as a medicament, for the manufacture of such a medicament, and in a method of treating a mammal, including man.
Inventors:
Franson, Jonas
Mosharraf, Mitra
Leticari, Lina
Wotilla, Shinika
Visli, Kalevi
Mosharraf, Mitra
Leticari, Lina
Wotilla, Shinika
Visli, Kalevi
Application Number:
JP2004535333A
Publication Date:
April 27, 2006
Filing Date:
September 12, 2003
Export Citation:
Assignee:
Pfizer Health AB
International Classes:
C07K14/61; A61K9/10; A61K38/27; A61P5/10; C07K1/14
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho