IL-17産生の阻害 - GENENTECH,INC.

Title:

IL-17産生の阻害

Document Type and Number:

Japanese Patent JP2006514004

Kind Code:

A

Abstract:

The invention concerns inhibition of the production of proinflammatory cytokine Interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23). The invention further concerns the use of IL-23 antagonists in the treatment of inflammatory diseases characterized by the presence of elevated levels of IL-17. IL-23 antagonists include, without limitation, antibodies specifically binding to a subunit or IL-17 or an IL-17 receptor. The invention additionally concerns induction of IL-17 production by using an IL-23 agonist.

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Inventors:

Gurney, Austin Elle.

Application Number:

JP2004550229A

Publication Date:

April 27, 2006

Filing Date:

October 29, 2003

Export Citation:

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Assignee:

GENENTECH,INC.

International Classes:

A61K45/00; A61K39/395; A61P1/04; A61P3/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P25/28; A61P29/00; A61P31/04; A61P37/02; A61P37/06; C07K16/24; G01N33/68; C12N15/09

Other References:

JPN7009005303; Ｍａｅｙａｍａ，Ｔ．　ｅｔ　ａｌ．: 'Ａｔｔｅｎｕａｔｉｏｎ　ｏｆ　ｂｌｅｏｍｙｃｉｎ-ｉｎｄｕｃｅｄ　ｐｎｅｕｍｏｐａｔｈｙ　ｉｎ　ｍｉｃｅ　ｂｙ　ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｔｏ　ｉｎｔｅｒｌｅｕｋｉｎ-１２' Ａｍ．　Ｊ．　Ｐｈｙｓｉｏｌ．　Ｌｕｎｇ　Ｃｅｌｌ　Ｍｏｌ．　Ｐｈｙｓｉｏｌ．Ｖｏｌ．２８０，Ｎｏ．６, 200106, Ｐ．Ｌ１１２８-Ｌ１１３７
JPN5005010567; Ｂｅｎｓｏｎ，Ｊ．　ｅｔ　ａｌ．: 'Ｔｈｅ　ｒｏｌｅ　ｏｆ　ＩＬ-２３　ｉｎ　ｅｘｐｅｒｉｍｅｎｔａｌ　ａｕｔｏｉｍｍｕｎｅ　ｅｎｃｅｐｈａｌｏｍｙｅｌｉｔｉｓ' ＦＡＳＥＢ　Ｊ．Ｖｏｌ．１６，Ｎｏ．５, 20020322, Ｐ．Ａ１０４５
JPN6013010911; ＩＮＦＥＣＴＩＯＮ　ＡＮＤ　ＩＭＭＵＮＩＴＹｖｏｌ．６９，Ｎｏ．７, 200107, ｐｐ４２３２-４２４１
JPN6013010912; Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｙｖｏｌ．１６１，Ｎｏ．９, 199811, ｐｐ５０９７-５１０４
JPN6013010913; ＧＵＴｖｏｌ．５２，Ｎｏ．１, 200301, ｐｐ６５-７０
JPN7013000882; Ｍｕｌｔｉｐｌｅ　Ｓｃｌｅｒｏｓｉｓｖｏｌ．５，Ｎｏ．２, 199904, ｐｐ１０１-１０４

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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