Title:
ファルネシルベンゾジアゼピノンの製造方法及び薬剤としての使用
Document Type and Number:
Japanese Patent JP2006515874
Kind Code:
A
Abstract:
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
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Inventors:
Buckman Bryan Oh
Mucarpin James Bee
Zazopros Emanuel
Farnet Chris M
Pyrah Mahmoud
Mucarpin James Bee
Zazopros Emanuel
Farnet Chris M
Pyrah Mahmoud
Application Number:
JP2006500437A
Publication Date:
June 08, 2006
Filing Date:
January 21, 2004
Export Citation:
Assignee:
Ecopia Biosciences Inc.
International Classes:
C07D243/38; A61K31/551; A61P29/00; A61P31/04; A61P35/00; C07K14/195; C12N1/20; C12N1/21; C12N9/00; C12N9/02; C12N9/10; C12N9/12; C12N9/14; C12N9/88; C12N9/90; C12N15/09; C12N15/52; C12P17/10; C12P17/18; C12P21/02; A61K38/00; C12R1/00; C12R1/29
Foreign References:
| US5541181A | 1996-07-30 | |||
| US5541181A | 1996-07-30 |
Attorney, Agent or Firm:
Masaki Hirota
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