Title:
α-フェトタンパク質Immu31抗体および融合タンパク質ならびにその使用方法
Document Type and Number:
Japanese Patent JP2006516086
Kind Code:
A
Abstract:
The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.
Inventors:
Hans, Hansen
Zenshin, Ku
David, M. Goldenberg
Zenshin, Ku
David, M. Goldenberg
Application Number:
JP2004525545A
Publication Date:
June 22, 2006
Filing Date:
August 01, 2003
Export Citation:
Assignee:
IMMUNOMEDICS, INC.
International Classes:
C12N15/00; A61K9/127; A61K38/00; A61K39/395; A61K41/00; A61K45/00; A61K47/48; A61K49/00; A61K49/04; A61K51/00; A61K51/10; A61P35/00; A61P37/00; C07K16/18; C07K16/30; C07K16/32; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12Q1/68; G01N33/574; G01N33/68; C12P21/08
Domestic Patent References:
| JPH08508488A | 1996-09-10 | |||
| JPH0390037A | 1991-04-16 | |||
| JPS60259963A | 1985-12-23 |
Foreign References:
| WO1996037516A1 | 1996-11-28 |
Other References:
JPN6009021923, Ｃｌｉｎ． Ｃａｎｃｅｒ Ｒｅｓ．, 199910, Ｖｏｌ．５， Ｎｏ．１０ Ｓｕｐｐｌ．, ｐｐ．３０９５ｓ−３１００ｓ
JPN6009021928, Ｊ． Ｎｕｃｌ． Ｍｅｄ．, 200205, Ｖｏｌ．４３， Ｎｏ．５, ｐｐ．６９３−７１３
JPN6009021931, Ｊ． Ｃｌｉｎ． Ｏｎｃｏｌ．, 199707, Ｖｏｌ．１５， Ｎｏ．７, ｐｐ．２６８３−２６９０
JPN6009021928, Ｊ． Ｎｕｃｌ． Ｍｅｄ．, 200205, Ｖｏｌ．４３， Ｎｏ．５, ｐｐ．６９３−７１３
JPN6009021931, Ｊ． Ｃｌｉｎ． Ｏｎｃｏｌ．, 199707, Ｖｏｌ．１５， Ｎｏ．７, ｐｐ．２６８３−２６９０
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota