Title:
S-[2-[(1-イミノエチル)アミノ]エチル]-2-メチル-L-システインマレエート塩酸塩結晶塩
Document Type and Number:
Japanese Patent JP2006519838
Kind Code:
A
Abstract:
A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride.
Inventors:
Ahmad Seek
Lyle Earl Brostrom
Anne M Chijuski
Verhid Zia
Lyle Earl Brostrom
Anne M Chijuski
Verhid Zia
Application Number:
JP2006506318A
Publication Date:
August 31, 2006
Filing Date:
March 04, 2004
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
C07C323/58; A61K31/198; A61K31/223; A61P1/12; A61P3/10; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P15/08; A61P19/02; A61P25/00; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P27/06; A61P29/00; C07C319/20; C07C319/28; C07C323/39; C07C323/59
Domestic Patent References:
| JP2004509098A | 2004-03-25 | |||
| JP2004509096A | 2004-03-25 | |||
| JP2000026402A | 2000-01-25 |
Foreign References:
| WO2001072702A2 | 2001-10-04 | |||
| WO2001072703A1 | 2001-10-04 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa