Title:
治療薬
Document Type and Number:
Japanese Patent JP2006520326
Kind Code:
A
Abstract:
The present invention provides compounds, compositions and methods for inhibiting or reducing reactive oxygen species (ROS) production in cells, such as in cells of the vascular system and in particular the smooth muscle-containing vasculature and/or endothelial cell-containing vasculature and/or adventitial fibroblast-containing vasculature. ROS production may also be inhibited in non-vascular cells of animals including mammals such as humans. Non-vascular cells contemplated herein include nerve cells, stem cells, progenitor cells and some cancer and rumor cells. More particularly, the present invention provides agents and even more particularly, cell-impermeable agents, capable of modulating NADPH oxidase activity, function or levels, thereby controlling superoxide production and production of downstream ROS. The present invention particularly enables agents which are selective against a form of Nox4-containing NADPH oxidase which has a portion of the enzyme such as all or part of the Nox4 component extracellularly exposed.
Inventors:
Dusting gregory james
Drummond Grant Raymond
Sobay Christopher Graeme
Drummond Grant Raymond
Sobay Christopher Graeme
Application Number:
JP2006501385A
Publication Date:
September 07, 2006
Filing Date:
February 27, 2004
Export Citation:
Assignee:
Howard Flory Institute of Experimental Physiology and Medicine
International Classes:
A61K45/00; A01K67/027; A61K31/00; A61K31/12; A61K31/167; A61K31/17; A61K31/33; A61K31/445; A61K31/495; A61K31/53; A61K31/7088; A61K38/00; A61K48/00; A61P1/02; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P13/12; A61P19/00; A61P35/00; A61P39/06; A61P43/00; C12N9/08; C12N9/99; C12N15/09
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi