Title:
神経保護大環状化合物及びそれらの使用方法
Document Type and Number:
Japanese Patent JP2006523213
Kind Code:
A
Abstract:
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroacetate. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or neuronal cell death caused by in embodiments, toxicity or hypoxia. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.
Inventors:
Harris Paul W Earl
Brimble Margaret Ann
Brimble Margaret Ann
Application Number:
JP2006507261A
Publication Date:
October 12, 2006
Filing Date:
March 16, 2004
Export Citation:
Assignee:
Nuren Pharmaceuticals Limited
Nuren Pharmaceuticals, Inc.
Nuren Pharmaceuticals, Inc.
International Classes:
C07K5/062; A61K31/395; A61K38/00; A61K39/395; A61K45/00; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P31/00; A61P37/00; A61P43/00; C07D225/00; C07D245/04; C07D471/04; C07D487/04; C07K5/083; A61K
Domestic Patent References:
| JPH09509404A | 1997-09-22 |
Foreign References:
| WO2002094856A2 | 2002-11-28 |
Other References:
JPN6009060927, Ｔｅｔｒａｈｅｄｒｏｎ （１９９７） ｖｏｌ．５３， ｎｏ．３８， ｐ．１２７８９−１２８５４
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama