Title:
医薬的に活性な化合物を調節して導入する方法
Document Type and Number:
Japanese Patent JP2006523723
Kind Code:
A
Abstract:
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. The compounds precipitate in aqueous environments. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a period of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.
Inventors:
Mercy, Jeramiribuy. S. N.
Suva, Robert H.
Suva, Robert H.
Application Number:
JP2006513123A
Publication Date:
October 19, 2006
Filing Date:
April 15, 2004
Export Citation:
Assignee:
IDEX Laboratories, Inc.
International Classes:
A61K9/08; A61K31/65; A61K31/7052; A61K47/12; A61K47/34; A61P11/00; A61P31/00; A61P43/00; A61K9/00; A61K47/10; A61K47/14; A61K47/20; A61K47/22; A61K47/26; A61K
Domestic Patent References:
| JP2001512487A | 2001-08-21 | |||
| JPH11171794A | 1999-06-29 | |||
| JPH02115118A | 1990-04-27 | |||
| JPH01149732A | 1989-06-12 | |||
| JPH08157391A | 1996-06-18 | |||
| JPH08508032A | 1996-08-27 | |||
| JP2001517613A | 2001-10-09 | |||
| JP2005511477A | 2005-04-28 | |||
| JPH04505762A | 1992-10-08 |
Foreign References:
| WO1999056725A1 | 1999-11-11 | |||
| US5574020A | 1996-11-12 |
Other References:
JPN6009023824, Ｍ．Ｈ．Ｒａｇｈｉｂ ｅｔ ａｌ．, "Ｓｍａｌｌ−ａｎｉｍａｌ Ｓｔｕｄｉｅｓ ｏｆ Ｐｏｔｅｎｔｉａｌ Ｃｏｐｐｅｒ−ｃｏｎｔａｉｎｉｎｇ Ｉｎｊｅｃｔａｂｌｅｓ", Ｊ Ｃｏｎｔｒｏｌ Ｒｅｌｅａｓｅ．, 1989, Ｖｏｌ．９, ｐ．５７−６４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama