Title:
糖尿病性ネフロパシーのラットモデル
Document Type and Number:
Japanese Patent JP2006527999
Kind Code:
A
Abstract:
A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat would develop progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy in the absence of the test compound, and (b) comparing the rat's development of diabetic nephropathy with a control T2DN mimic rat that has not been exposed to the test compound.
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Inventors:
Jacob, Howard Jay.
Roman, Richard Jay.
Nobrega, marcelo
Roman, Richard Jay.
Nobrega, marcelo
Application Number:
JP2006521233A
Publication Date:
December 14, 2006
Filing Date:
July 21, 2004
Export Citation:
Assignee:
MC DUBRYU Research Foundation Inc.
International Classes:
A01K67/027; A61K49/00; C12N5/06; C12N5/10; C12N15/85; G01N33/68
Other References:
JPN5006010435, ＮＯＢＲＥＧＡ ＭＡＲＣＥＬＯ Ａ, ＤＩＡＢＥＴＥＳ, 200403, Ｖ５３ Ｎ３, Ｐ７３５−７４２
Attorney, Agent or Firm:
Takao Kawasaki
Toshizo Iida
Toshizo Iida