Title:
乱用抵抗性アンフェタミン化合物類
Document Type and Number:
Japanese Patent JP2007500242
Kind Code:
A
Abstract:
The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
Inventors:
Mikuru, Travis
Krishnan, Suma
Bishop, Bernie
Loader back, Christopher
Moncliffe, James, Scott
Obel render, rob
Krishnan, Suma
Bishop, Bernie
Loader back, Christopher
Moncliffe, James, Scott
Obel render, rob
Application Number:
JP2006533534A
Publication Date:
January 11, 2007
Filing Date:
June 01, 2004
Export Citation:
Assignee:
New River Pharmaceuticals, Inc.
International Classes:
A61K47/48; A61K9/08; A61K9/10; A61K9/20; A61K9/48; A61K9/72; A61K31/165; A61K31/198; A61K38/00; A61K47/38; A61P3/04; A61P25/18; A61P25/20; A61P25/30; A61K31/137; A61K31/4458
Foreign References:
| FR1421130A | 1965-12-10 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Shinji Oga
Toshifumi Onuki
Shinji Oga
Toshifumi Onuki