Title:
記憶および認知保護法
Document Type and Number:
Japanese Patent JP2007502332
Kind Code:
A
Abstract:
The invention features certain compounds useful in the treatment of memory disorders, i.e., they reduce or delay memory loss or they enhance memory retention. Because certain of the compounds do not substantially inhibit either COX-1 or COX-2 at therapeutically relevant doses, these compounds are far less likely to cause gastrointestinal ulceration than is indomethacin, which is known to inhibit both COX-1 and COX-2. Certain of the compounds inhibit the activity of DAO at therapeutically relevant doses. Among the memory disorders that can be treated are AD, mild cognitive impairment (MCI; a common precursor to AD), and memory loss or cognitive impairment associated with vascular dementias, amnesia, dementia, AIDS dementia, Huntington's Disease, hydrocephalus, depression, Pick's Disease, Creutzfeldt-Jakob Syndrome, electroconvulsive therapy, or Parkinson's Disease.
Inventors:
Curry, Brian M.
Chen, You-Ting
Curry, Mark Gee.
Tally, John Jeffrey
Zimmerman, Craig
Chen, You-Ting
Curry, Mark Gee.
Tally, John Jeffrey
Zimmerman, Craig
Application Number:
JP2006533556A
Publication Date:
February 08, 2007
Filing Date:
June 01, 2004
Export Citation:
Assignee:
Microbia,Inc.
International Classes:
A61K31/405; A01N43/36; A01N43/38; A61K31/40; A61K31/4439; A61K31/454; A61K31/55; A61K45/00; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P31/18; C07D209/02; C07D209/18; C07D209/26; C07D209/28; C07D401/06; C07D405/00; C07D409/00; C07D411/00; A61K
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda