Title:
口腔粘膜を介して5-HTアゴニストを運搬するための組成物及びその使用方法
Document Type and Number:
Japanese Patent JP2007502839
Kind Code:
A
Abstract:
The present invention provides novel compositions for the delivery of a 5-hydroxytryptamine (5-HT) agonist across the oral mucosa. In particular, the buffer system in the compositions of the present invention raises the pH of saliva to a pH greater than about 9.9, thereby facilitating the substantially complete conversion of the 5-HT agonist from its ionized to its unionized form. As a result, the dose of 5-HT agonist is rapidly and efficiently absorbed by the oral mucosa. Furthermore, delivery of the 5-HT agonist across the oral mucosa advantageously bypasses hepatic first pass metabolism of the drug and avoids enzymatic degradation of the drug within the gastrointestinal tract. Methods for using the compositions of the present invention for treating migraines are also provided.
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Inventors:
Shin, Nikiresh N.
Application Number:
JP2006524083A
Publication Date:
February 15, 2007
Filing Date:
August 18, 2004
Export Citation:
Assignee:
Transoral Pharmaceuticals, Incorporated
International Classes:
A61K45/00; A61K9/00; A61K9/22; A61K31/403; A61K31/404; A61K31/4045; A61K31/41; A61K31/4184; A61K31/4196; A61K31/422; A61K31/454; A61K47/02; A61K47/10; A61K47/26; A61K47/36; A61P25/06; A61P43/00; A61K
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Ayako Okamura
Takashi Ishida
Fukumoto product
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Ayako Okamura