Title:
ヒトカテプシンGのためのDNAに基づくアプタマー
Document Type and Number:
Japanese Patent JP2007506413
Kind Code:
A
Abstract:
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions.The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chaing length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
Inventors:
Palumbo, Manrio
Gatto, Barbara
Pescador, Rodolfo
Roberto, Porta
Ferlo, Laura, Iris
Gatto, Barbara
Pescador, Rodolfo
Roberto, Porta
Ferlo, Laura, Iris
Application Number:
JP2006518010A
Publication Date:
March 22, 2007
Filing Date:
June 18, 2004
Export Citation:
Assignee:
Gentium SP
International Classes:
A61K31/711; C12N15/09; A61P7/02; A61P17/00; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C12N15/115; A61K38/00
Domestic Patent References:
| JPH06508022A | 1994-09-14 | |||
| JPH09216895A | 1997-08-19 |
Attorney, Agent or Firm:
Mitsuo Matsui