Title:
キラルプロピオン酸誘導体の製造方法
Document Type and Number:
Japanese Patent JP2007506800
Kind Code:
A
Abstract:
The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R1, R2, R3 and R4 are as defined in the specification and claims. The compounds of formula I and the corresponding salts and/or esters are pharmaceutically active substances.
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Inventors:
Puenter, Kurt
Scallone, michelangelo
Scallone, michelangelo
Application Number:
JP2006530000A
Publication Date:
March 22, 2007
Filing Date:
September 21, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D413/12; C07B53/00; C07B61/00
Domestic Patent References:
| JPH0632780A | 1994-02-08 | |||
| JP2000044552A | 2000-02-15 |
Foreign References:
| WO2002092084A1 | 2002-11-21 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda