Title:
ホスホジエステラーゼ-4阻害剤としてのアザベンゾジアゼピン
Document Type and Number:
Japanese Patent JP2007509127
Kind Code:
A
Abstract:
Compounds of formula (I): characterized in that: . Rl represents a group selected from hydrogen atom, methyl, methoxy, hydroxy, amino, dimethylamino, acetamido, pyrrolidin-l-yl, and hydroxymethyl; . R2 represent a group selected from phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, indolyl, pyrolyl, [1,2,3]-triazolyl, benzo[c]isoxazolyl, thienyl, pyrazolyl, isothiazolyl, imidazolyl, benzofuranyl, pyrazolo[5,1-c][1,2,4]triazyl each of these groups being optionally substituted from 1 to 3 groups, identical or different independently of each other, selected from halogen, trifluoromethyl, (C1-C4)alkyl, (CI-C4)alkoxy, hydroxy, amino, acetamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acetylmethoxy, cyclopentyloxy; optionally, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as active ingredient in pharmaceutical composition useful for treating diseases involving therapy by inhibition of PDE4.
Inventors:
Ingrid Devils
Bernard Gaudilière
Henry Jacoberg
Isabel Pevette
Bernard Gaudilière
Henry Jacoberg
Isabel Pevette
Application Number:
JP2006536201A
Publication Date:
April 12, 2007
Filing Date:
October 18, 2004
Export Citation:
Assignee:
Warner-Lambert Company Limited Liability Company
International Classes:
C07D471/06; A61K31/55; A61K31/551; A61P1/04; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P19/10; A61P25/22; A61P25/24; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D471/04; C07D471/16
Attorney, Agent or Firm:
Yoshinobu Murofushi