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Patent Searching and Data

Document Type and Number:
Japanese Patent JP2007509178
Kind Code:
A formulation comprised of four active components which are a lipid soluble thiamine, lipoic acid, arginine alpha-ketoglutarate, and a creatine derivative for oral administration is disclosed. The active components may be combined with excipient materials in such a way that those materials provide for an immediate release of a first portion of the active ingredients from the formulation following by a gradual release of any remaining active ingredients in a manner which makes it possible to (1) quickly obtain a therapeutic level of the active ingredients; and (2) substantially increase the period of time over which therapeutic levels of the active ingredients are maintained relative to a quick release formulation. These features make it possible to use the formulation to obtain a range of beneficial effects including reducing serum glucose levels and maintaining those reduced glucose levels over time to treat diabetic polyneuropathy as well as improving circulation and increasing muscle performance.

Bird Edward A.
Application Number:
Publication Date:
April 12, 2007
Filing Date:
October 22, 2004
Export Citation:
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Medical Research Institute
International Classes:
A61K31/51; A61K9/20; A61K31/155; A61K31/194; A61K31/197; A61K31/198; A61K31/223; A61K31/385; A61K31/425; A61K31/426; A61K31/64; A61K45/06; A61P1/04; A61P1/10; A61P1/12; A61P3/02; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P21/00; A61P25/00; A61P25/08; A61P25/16; A61P25/20; A61P25/24; A61P25/28; A61P27/02; A61P27/12; A61P29/00; A61P31/00; A61P39/06; A61P43/00; A61K9/50
Domestic Patent References:
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi