Title:
BACE455、ヒトβ-セクレターゼの選択的スプライシング変異体
Document Type and Number:
Japanese Patent JP2007510425
Kind Code:
A
Abstract:
The present invention relates generally to the fields of genetics, biochemistry, medicinal chemistry and medicine. The present invention more particularly discloses the identification of a human gene variant involved in neuropathological conditions, and methods for the diagnosis, prevention and treatment of such diseases and related disorders, as well as for the screening of therapeutically active drugs. The present invention relates to catalytically active beta-secretase (Memapsin2, BACE) variants, and nucleic acids encoding them. The invention is useful in the identification of agents that inhibit the activity of a particular BACE isoform and thus agents and therapies affecting the genesis, development or progression of neuropathological conditions, including Alzheimer's disease and dementia.
Inventors:
Desiree, Laurent
Application Number:
JP2006538996A
Publication Date:
April 26, 2007
Filing Date:
November 05, 2004
Export Citation:
Assignee:
EXONHIT THERAPEUTICS SA
International Classes:
C12N15/09; A61K39/395; A61K45/00; A61P3/10; A61P7/02; A61P7/06; A61P9/10; A61P9/12; A61P9/14; A61P21/00; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/10; A61P29/00; A61P31/00; A61P31/04; A61P31/06; A61P31/10; A61P31/12; A61P31/18; A61P33/02; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07K14/47; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12N9/99; C12P21/08; C12Q1/37; C12Q1/68; G01N33/15; G01N33/50
Foreign References:
| WO2001046398A2 | 2001-06-28 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda