60Cu、61Cu、および64Cu放射性核種の自動分離、精製、および標識装置とその回収

Japanese Patent JP2007512118

A

A novel method for separating an irradiated ⁶⁰Cu or ⁶¹Cu or ⁶⁴Cu respectively from a composition containing ⁶⁰Ni or ⁶¹Ni or ⁶⁴Ni respectively therein comprises dissolving the irradiated ⁶⁰Cu or ⁶¹Cu or ⁶⁴Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising ⁶⁰Ni or ⁶¹Ni or ⁶⁴Ni ions. In an aspect the eluent is further processed for ⁶⁰Ni or ⁶¹Ni or ⁶⁴Ni recovery and recycling to prepare future targets. In an aspect ⁶⁰Cu or ⁶¹Cu or ⁶⁴Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the ⁶⁰Cu or ⁶¹Cu or ⁶⁴Cu for further use or labeling. An enhanced process for labeling compounds with highly purified ⁶⁰Cu, ⁶¹Cu or ⁶⁴Cu comprises loading ⁶⁰Cu, ⁶¹Cu and ⁶⁴Cu elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-muL of ligand and 3N HCl solution in a reaction line to form a ^{60 or 61 or 64}Cu labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the C₁₈ Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and recovering ⁶⁰Cu, ⁶¹Cu and ⁶⁴Cu each as a separate and independent purified product.

Welch, Michael John
Tan, Lucy Liwa
Gale, Gregory Glen
Lewis, Jason Stewart

JP2006523275A

May 17, 2007

August 09, 2004

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WASHINGTON UNIVERSITY IN ST.LOUIS

B01D59/30; G01T1/161; G21G4/08; C07C

US6011825A	2000-01-04
US6801813B2	2004-10-05

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura
Masaya Nishiyama

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