Title:
宿主細胞から標的細胞へのギャップジャンクションを介したDNAまたはRNAの送達、及びアンチセンスまたはsiRNAのための細胞ベースの送達システム
Document Type and Number:
Japanese Patent JP2007514445
Kind Code:
A
Abstract:
A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
Inventors:
Peter Earl Brink
Michael Earl Rosen
Richard B Robinson
Ira S. Cohen
Arthur Grollmann
Michael Earl Rosen
Richard B Robinson
Ira S. Cohen
Arthur Grollmann
Application Number:
JP2006545489A
Publication Date:
June 07, 2007
Filing Date:
December 17, 2004
Export Citation:
Assignee:
The Trustees of Columbia University in the City of New York
The Research Foundation of State University of New York
The Research Foundation of State University of New York
International Classes:
C12N15/09; A61K48/00; A61P35/00; C12N5/10; C12N15/87; C12N
Other References:
JPN6010047020, Ｊ． Ｃｅｌｌ Ｓｃｉ．， Ａｕｇ．２００３， Ｖｏｌ．１１６， ｐ．３４１３−３４２１
JPN6010047021, 蛋白質 核酸 酵素， ２００１， Ｖｏｌ．４６， Ｎｏ．１０， ｐ．１３６７−１３７３
JPN6010047022, Ｂｏｎｅ， １９９９， Ｖｏｌ．２５， Ｎｏ．６， ｐ．６６１−６６６
JPN6010047023, Ａｍ． Ｊ． Ｐｈｙｓｉｏｌ． Ｈｅａｒｔ Ｃｉｒｃ． Ｐｈｙｓｉｏｌ．， ２００１， Ｖｏｌ．２８１， ｐ．Ｈ１６７５−Ｈ１６８９
JPN6010047024, Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ．， １９９３， Ｖｏｌ．９１， ｐ．９９７−１００４
JPN6010047025, Ｃｉｒｃ． Ｒｅｓ．， ２００２， Ｖｏｌ．９１， ｐ．１０４−１１１
JPN6010047021, 蛋白質 核酸 酵素， ２００１， Ｖｏｌ．４６， Ｎｏ．１０， ｐ．１３６７−１３７３
JPN6010047022, Ｂｏｎｅ， １９９９， Ｖｏｌ．２５， Ｎｏ．６， ｐ．６６１−６６６
JPN6010047023, Ａｍ． Ｊ． Ｐｈｙｓｉｏｌ． Ｈｅａｒｔ Ｃｉｒｃ． Ｐｈｙｓｉｏｌ．， ２００１， Ｖｏｌ．２８１， ｐ．Ｈ１６７５−Ｈ１６８９
JPN6010047024, Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ．， １９９３， Ｖｏｌ．９１， ｐ．９９７−１００４
JPN6010047025, Ｃｉｒｃ． Ｒｅｓ．， ２００２， Ｖｏｌ．９１， ｐ．１０４−１１１
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro