ワクチン - GlaxoSmithKline Biologicals Society Anonymous

Title:

ワクチン

Document Type and Number:

Japanese Patent JP2007515180

Kind Code:

A

Abstract:

The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.

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Inventors:

Boss, Martine, Petronella
Poolman, Jean
Boris Tefsen
Tomasen, Johannes, Petrus, Maria

Application Number:

JP2006546095A

Publication Date:

June 14, 2007

Filing Date:

December 21, 2004

Export Citation:

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Assignee:

GlaxoSmithKline Biologicals Society Anonymous
Utrecht University

International Classes:

C12N15/09; A61K35/74; A61K39/095; A61K39/395; A61K45/00; A61K47/26; A61P31/04; C07K14/195; C07K14/22; C07K14/315; C07K16/12; C07K19/00; C12N1/20; C12N1/21; C12P21/02; A61K39/00; C12R1/36

Domestic Patent References:

JP2001514001A	2001-09-11
JPH1192398A	1999-04-06

Foreign References:

WO2002079243A2	2002-10-10
WO2002016612A2	2002-02-28
EP0011243B1	1982-04-14
WO2002079243A2	2002-10-10

Other References:

JPN6010059705; ＢＯＳ，Ｍ．Ｐ．　ｅｔ　ａｌ．: Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡＶｏｌ．１０１，　Ｎｏ．２５, 20040622, ｐｐ．９４１７-９４２２
JPN6010059706; ＳＴＥＥＧＨＳ，Ｌ．　ｅｔ　ａｌ．: ＮａｔｕｒｅＶｏｌ．３９２, 19980402, ｐｐ．４４９-４５０
JPN6010059707; ＧＥＮＥＶＲＯＩＳ，Ｓ．　ｅｔ　ａｌ．: ＥＭＢＯ　Ｊ．Ｖｏｌ．２２，　Ｎｏ．８, 200304, ｐｐ．１７８０-１７８９
JPN6010059702; ＢＲＡＵＮ，Ｍ．　ａｎｄ　ＳＩＬＨＡＶＹ，Ｔ．Ｊ．: Ｍｏｌ．　Ｍｉｃｒｏｂｉｏｌ．Ｖｏｌ．４５，　Ｎｏ．５, 2002, ｐｐ．１２８９-１３０２
JPN6010059703; ＺＨＯＵ，Ｚ．　ｅｔ　ａｌ．: Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．Ｖｏｌ．２７３，　Ｎｏ．２０, 1998, ｐｐ．１２４６６-１２４７５
JPN6010059704; Ｄａｔａｂａｓｅ　ＵｎｉＰｒｏｔＫＢ／Ｓｗｉｓｓ-Ｐｒｏｔ［ｏｎｌｉｎｅ］: Ａｃｃｅｓｓｉｏｎ　Ｎｏ．Ｐ２７２９９ , 20031128
JPN6010059705; ＢＯＳ，Ｍ．Ｐ．　ｅｔ　ａｌ．: Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡＶｏｌ．１０１，　Ｎｏ．２５, 20040622, ｐｐ．９４１７-９４２２
JPN6010059706; ＳＴＥＥＧＨＳ，Ｌ．　ｅｔ　ａｌ．: ＮａｔｕｒｅＶｏｌ．３９２, 19980402, ｐｐ．４４９-４５０
JPN6010059707; ＧＥＮＥＶＲＯＩＳ，Ｓ．　ｅｔ　ａｌ．: ＥＭＢＯ　Ｊ．Ｖｏｌ．２２，　Ｎｏ．８, 200304, ｐｐ．１７８０-１７８９

Attorney, Agent or Firm:

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita

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