Title:
インドール、アザインドール、および関連するヘテロ環状N-置換ピペラジン誘導体
Document Type and Number:
Japanese Patent JP2007516205
Kind Code:
A
Abstract:
This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is
Inventors:
Yong Kap-Sun
Michelle Fercus
John F Cado
Nicholas A. Meanwell
Malcolm Taylor
David Johnston
Thomas Stephen Coulter
Jay Jay Kim Wright
Michelle Fercus
John F Cado
Nicholas A. Meanwell
Malcolm Taylor
David Johnston
Thomas Stephen Coulter
Jay Jay Kim Wright
Application Number:
JP2006518663A
Publication Date:
June 21, 2007
Filing Date:
June 22, 2004
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D413/14; A61K31/405; A61K31/4745; A61K31/496; A61K31/497; A61K31/498; A61K31/502; A61K31/517; A61K45/00; A61P31/00; A61P31/18; A61P37/02; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D471/02; C07D471/04; C07D487/04; C07D491/04; C07D491/048
Domestic Patent References:
| JP2003501476A | 2003-01-14 | |||
| JPH05503929A | 1993-06-24 | |||
| JPH10510530A | 1998-10-13 | |||
| JPH0797364A | 1995-04-11 | |||
| JP2000505098A | 2000-04-25 | |||
| JP2007529519A | 2007-10-25 |
Foreign References:
| WO2001062255A1 | 2001-08-30 | |||
| US20030069266A1 | 2003-04-10 | |||
| WO2002085301A2 | 2002-10-31 | |||
| WO2002004440A1 | 2002-01-17 | |||
| US3188313A | 1965-06-08 | |||
| US3135794A | 1964-06-02 | |||
| GB944443A | ||||
| US6232327B1 | 2001-05-15 |
Other References:
JPN6010032038, Ｒｏｍｅｒｏ， Ｄ． Ｌ． ｅｔ ａｌ．, "”Ｄｉｓｃｏｖｅｒｙ， Ｓｙｎｔｈｅｓｉｓ， ａｎｄ Ｂｉｏａｃｔｉｖｉｔｙ ｏｆ Ｂｉｓ（ｈｅｔｅｒｏａｒｙｌ）ｐｉｐｅｒａｚｉｎｅｓ． １． Ａ Ｎｏｖｅｌ Ｃｌａｓｓ ｏｆ Ｎｏｎ−Ｎｕｃｌｅｏ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1994, Ｖｏｌ．３７， Ｎｏ．７, ｐ．９９９−１０１４, US, Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ
Attorney, Agent or Firm:
Kyousei Tamura
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa