Title:
N-置換-N-スルホニルアミノシクロプロパン化合物及びその医薬用途
Document Type and Number:
Japanese Patent JP2007516981
Kind Code:
A
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) wherein R1 is -W-A1-W1-A2, W is -(CH2)m-X-(CH2)n-, wherein W1 is -(CH2)m1-X1-(CH2)n1-, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is -(CH2)r-CO-R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is -CO2R21, etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
Inventors:
Flyer Andrew M
Makoto Shiozaki
Littman Nicole M
Takayuki Inaba
Andrews Stephen W
Katsuhisa Yasue
Laird Ellen Earl
Yokota Masahiro
Hearth Julia
Hiroto Imai
Katsuya Maeda
Yuichi Shinozaki
Yoshikazu Hori
Makoto Shiozaki
Littman Nicole M
Takayuki Inaba
Andrews Stephen W
Katsuhisa Yasue
Laird Ellen Earl
Yokota Masahiro
Hearth Julia
Hiroto Imai
Katsuya Maeda
Yuichi Shinozaki
Yoshikazu Hori
Application Number:
JP2006545807A
Publication Date:
June 28, 2007
Filing Date:
December 14, 2004
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
C07C311/20; A61K31/18; A61K31/198; A61K31/27; A61K31/33; A61K31/341; A61K31/381; A61K31/40; A61K31/401; A61K31/403; A61K31/41; A61K31/415; A61K31/4152; A61K31/4184; A61K31/4196; A61K31/4245; A61K31/426; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/445; A61K31/4465; A61K31/496; A61K31/536; A61K31/5375; A61K31/5377; A61K31/551; A61K31/553; A61P19/02; A61P29/00; A61P43/00; C07C311/51; C07C381/06; C07C381/08; C07D207/34; C07D209/02; C07D209/52; C07D211/34; C07D211/46; C07D211/60; C07D213/42; C07D213/65; C07D213/74; C07D213/79; C07D213/80; C07D221/02; C07D231/14; C07D231/20; C07D233/64; C07D233/90; C07D235/14; C07D249/10; C07D249/12; C07D257/04; C07D257/06; C07D261/18; C07D271/06; C07D271/07; C07D277/20; C07D277/56; C07D285/06; C07D285/08; C07D285/10; C07D295/08; C07D295/088; C07D295/092; C07D295/10; C07D295/13; C07D295/15; C07D295/185; C07D307/68; C07D333/18; C07D333/34; C07D409/12; C07D413/02; C07D413/04; C07D413/12; C07D235/10
Attorney, Agent or Firm:
Ryu Iwatani