Title:
免疫調節アルカロイド
Document Type and Number:
Japanese Patent JP2007518785
Kind Code:
A
Abstract:
Immunotherapy comprises administration of an alkaloid at a dose sufficient to induce IL-2 production in dendritic cells in a patient. The alkaloid induces the production of IL-2 in dendritic cells. The alkaloids need not be naturally occurring, and may be synthetic analogues or derivatives of naturally occurring counterparts. Such analogues or derivatives are preferably pharmaceutically acceptable analogues, salts, isomers or derivatives as herein defined. However, preferred alkaloids are phytochemicals. Such phytochemicals may be isolated from natural sources or synthesised in vitro. Particularly preferred are alkaloids is selected from piperidine alkaloids; pyrrolin alkaloids; pyrrolidine alkaloids; pyrolizidine alkaloids: indolizidine alkaloids and nortropane alkaloids.
Inventors:
Robert, James, Nash
Allison, Ann, Watson
Emma, Luisa, Evvinson
Hadin, St., Pierre, Parry
Allison, Ann, Watson
Emma, Luisa, Evvinson
Hadin, St., Pierre, Parry
Application Number:
JP2006550281A
Publication Date:
July 12, 2007
Filing Date:
January 21, 2005
Export Citation:
Assignee:
M N L PHARMA LIMITED
International Classes:
A61K45/00; A61K31/40; A61K31/407; A61K31/437; A61K31/7028; A61K31/7056; A61K38/22; A61K39/00; A61K39/39; A61K45/06; A61P7/06; A61P11/06; A61P17/02; A61P31/04; A61P31/10; A61P31/12; A61P31/16; A61P31/18; A61P33/02; A61P33/06; A61P35/00; A61P35/04; A61P37/04; A61P37/08; A61P43/00; C12N5/07; C12N5/0784; C12N5/0786; C12N5/09; C07D207/12; C07D471/04; C07D487/04; C07H17/02
Domestic Patent References:
| JP2006515357A | 2006-05-25 |
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Hiroshi Sorimachi
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Hiroshi Sorimachi