Title:
立体異性強化アミンの製造方法
Document Type and Number:
Japanese Patent JP2007521801
Kind Code:
A
Abstract:
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, -(CR7R8)t(C6-C14 aryl), and -(CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, -OR7, and -N(R7R8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
Inventors:
Huh, Shanhui
Martinez, Carlos Alberto
Tao, Junhwa
Yasbeck, Daniel Lida
Martinez, Carlos Alberto
Tao, Junhwa
Yasbeck, Daniel Lida
Application Number:
JP2006542037A
Publication Date:
August 09, 2007
Filing Date:
November 22, 2004
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C12P41/00; C07C269/06; C07C269/08; C07C271/22; C07D207/16; C07D207/24; C07D277/06; C07D277/18; C07D417/02; C12P13/04; C12P13/24; C12P17/10; C12P17/14
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura