Title:
ジフルオロヌクレオシド及びその調製方法
Document Type and Number:
Japanese Patent JP2007522151
Kind Code:
A
Abstract:
A stereoselective process for the preparation of a 2',2'-difluronucleoside is provided. In the process, a protected 2'2'-difluorofuranose is coupled with a base selected from the group consisting of pyrimidine and purine derivatives in the presence of a Lewis acid, wherein the protected 2'2'-difluorofuranose has a 1-position leaving group and 3- and 5-position protecting groups, and, when the base comprises 1 or more oxygen atoms, the base is a protected base, wherein each oxygen atom is protected with a protecting group.
Inventors:
Bourne, Anne-Ruth
Martin, Pierre
Spier Vogel, Dirk
Villa, Marco
Martin, Pierre
Spier Vogel, Dirk
Villa, Marco
Application Number:
JP2006552382A
Publication Date:
August 09, 2007
Filing Date:
December 08, 2005
Export Citation:
Assignee:
Sicole Incorporated
International Classes:
C07H19/06
Domestic Patent References:
| JP62500239B |
Foreign References:
| US5744597A | 1998-04-28 | |||
| US5371210A | 1994-12-06 | |||
| US3748320A | 1973-07-24 | |||
| US4965374A | 1990-10-23 | |||
| US5594124A | 1997-01-14 | |||
| CN1442420A | 2003-09-17 | |||
| US5401838A | 1995-03-28 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura