Title:
シトクロムP450阻害剤としてのナフチレン誘導体
Document Type and Number:
Japanese Patent JP2007523866
Kind Code:
A
Abstract:
Compounds of the formula (I); and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G <1>,Q<1>, Z, R<1>, R<2>, R<3>, R<4a>, R<4b>, R<5a>, and R<5b> are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.
Inventors:
Smith, Spring
Negro, Anthony
Marvi Hill, Mark
Cesario, Kara
Beck, Patricia Ann
Castellano, Erlind Lucas
Negro, Anthony
Marvi Hill, Mark
Cesario, Kara
Beck, Patricia Ann
Castellano, Erlind Lucas
Application Number:
JP2006518965A
Publication Date:
August 23, 2007
Filing Date:
July 12, 2004
Export Citation:
Assignee:
OSI Pharmaceuticals Incorporated
International Classes:
C07D233/61; A61K9/02; A61K9/06; A61K9/10; A61K9/12; A61K9/14; A61K9/20; A61K9/48; A61K31/07; A61K31/203; A61K31/4174; A61K31/4178; A61K31/4192; A61K31/5377; A61P17/06; A61P35/00; A61P43/00; C07C217/70; C07C225/16; C07D207/08; C07D233/54; C07D249/04; C07D295/08; C07D295/10; C07D309/08; C07D403/10; C07D405/12
Domestic Patent References:
| JP2002080458A | 2002-03-19 | |||
| JP2000007658A | 2000-01-11 |
Foreign References:
| EP0218118A1 | 1987-04-15 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura